Wnt signalling, stem cells, drug discovery, biochemistry of Wnt signalling protein complexes, signalling pathway networks.
ES cell technologies, fat pad transplantation, protein biochemistry, high content screening
gene targetted mice (knock-out and transgenic) for components of the Wnt pathway. GFP and luciferase reporter readouts for Wnt pathway activity. We have developed new in vitro organoid culture models for the normal and transformed mammary epithelium.