Alex Swarbrick

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Garvan Institute of Medical Research
Stem cell pathways in mammary development, breast cancer and metastatic progression. MicroRNAs in cancer progression. Inhibitor of Differentiation proteins, Id1, Id2, Id3, Id4 Hedgehog pathway in breast cancer. Development of novel therapeutics / biomarkers for therapeutic response to existing agents
In vivo and in vitro stem and progenitor assays. In vivo imaging. Inducible gene expression and knockdown
Chimeric (transplant) Mouse models of mammary development and cancer. ID1- and ID4- GFP knock-in mice. LSL-SmoM2 and Ptc-LacZ knockin mice. C3-SV40 Large T transgenic. Cell lines in vivo: Comma-d-b, 4T1, M6, MDA-MB-231