Anne-Lise Børresen-Dale

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+47 22 78 13 73
Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
>20 years
The Department's Research vision is exploring The Systems Biology of Breast Cancer Our research program is focusing on the molecular biology of breast and ovarian cancer with emphasis on identification of genotypes and gene expression profiles contributing to elevated cancer risk, radiation sensitivity, tumor aggressiveness and therapy resistance. The hypothesis is that both the geno- and phenotype of the tumor as well as the patients own genotype (the genetic “makeup” of the patient constituted by both high and low penetrance genes) play a role in breast and ovarian cancer risk, in the type of cancer developed, the disease course and the response to treatment. The results may be used to identify high-risk individuals that may benefit from preventing strategies, and to individualize the treatment of patients with respect to choice of drugs as well as to dose and duration. This may give a better therapeutic effect and less adverse reactions in the individual patient. Goals: 1. To join forces and expertise to create a world-leading Breast Cancer Research Center including The Dept of Medical Statistic Faculty of Medicine, Dept of Informatics, Faculty of Mathematics and Natural Sciences, UiO, The Norwegian Radium Hospital, Ullevål Univ. Hospital and potentially other hospitals in the Oslo area 2. To follow the linear time course of predisposition, initiation, early stages and advanced disease and to dissect the molecular mechanisms triggered at each stage 3. To follow the multidimentional interactions at various levels in a systems biology approach
large scale analyses using various array technology to perform WGA on SNPs and CNVc, blood expression (mRNA and miRNA), Tumor mRNA and miRNA expression, aCGH, mutation, methylation and protein anaalyses using RPPA
large cohorts of breast cancer patients with long term follow up, and healty woman participating in a population based study NOWAC