Michigan State University
Bioinformatics, gene expression analysis, predictive signatures, mammary development, breast cancer, transgenics, knockouts, HER2/Neu, Myc, PyMT
We seek to integrate bioinformatics with breast biology. We predict the roles of key cell signaling pathways with signatures and gene expression data in mammary gland development and then test these predictions using mouse model systems.
MMTV-Myc, MMTV-Neu, MMTV-PyMT, E2F knockout mice