Gilles PAGES

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00 33 4 92 03 12 31
University of Nice Sophia Antipolis UMR CNRS 6543
Normal and tumor angiogenesis. We are looking at the regulation of angiogenic factor VEGf and IL-8 in particular at the post transcriptional level. We are studying mRNA binding protein that destabilizes the mRNA. We are looking at the loss of mRNA degradative protein in breast cancer on tumor cell lines and on tumor samples. We are also looking at the effect of targetted therapy on the expression of these proteins
Stable and transient transfection of genes of interest. In vivo imaging of tumor xenografts of cells with expression of luciferase. Determination of angiogenic factor by ELISA; Reporter genes (promoters and 3'UTR)
Cell with different metastatic potential with inducible expression of mRNA degradative protein, tumor samples