IFOM- Italian Foundation of Molecular Oncology
We are interested in understanding metabolic reprogramming during the initiation, progression and response of breast cancer using in vivo animal model systems and ex vivo organotypic cultures. We aim to understand how both genetic context and the local environment, shape metabolic reprogramming in breast cancer. Specifically, we are interested in understanding the extent of metabolic plasticity throughout the evolution of breast cancer, from disease onset up to and including therapeutic response. Through more thorough understanding of this key hallmark of breast cancer we aim to design strategies for more effective patient treatment.
primary organoid cultureacyl-biotin exchange
We use a combination of mouse models and organoid cultures to isolate cells which survive therapeutic treatment. This approach has allowed us to characterize residual breast cancer using multi-tiered systems biology approaches. Our goal is to utilize these platforms to identify more effective therapeutic options for breast cancer patients