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+32 9 332 3007
Laboratory of Experimental Cancer Research, Department of Radiotherapy and Nuclear Medicine, University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.
Mechanisms of tumor invasion and metastasis, mammary cancer, stromal interactions with cancer cells (myofibroblasts, adipocytes and stem cells), cytoskeleton and motility, cadherin/catenin complexes in cell-cell adhesion, endoplasmic reticulum stress, radiation-induced effects on invasion, new circulating tumor markers, invasion suppressor genes, early metastasis genes, hormones and breast cancer.
Organotypic confronting cultures for invasion, Western blot, immunoprecipitation, transfection, siRNA, time-lapse microscopy, immunohisto/cytochemistry, raising monoclonal antibodies, ELISA, assays for ER stress and apoptosis, cell irradiation, PCR…
3D-models for invasion in vitro (embryonic chick heart, type I collagen, Matrigel, reconstituted tissues), metastasis models in laboratory mice, aggregation models for cell-cell adhesion, interaction models between stromal and cancer cells, directional migration models (wound healing, checker board analysis, radial aggregate outgrowth).