R Charles Coombes

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R Charles
020 8383 5828
Imperial College
I run a laboratory of approximately 200 staff in which we are engaged in the development of new forms of treatment for breast cancer, particularly endocrine therapy. Over the past 20 years, my group has completed the clinical development of two steroidal aromatase inhibitors, including 4-hydroxyandrostenedione and exemestane and my laboratory is currently engaged in studies aimed at understanding the role of estrogen receptor a and estrogen receptor ß in human breast cancer. We are engaged in developing novel methods for prediction of response to endocrine therapy and also doing research aimed at understanding the mechanisms of resistance to endocrine therapy.